Franke H D, Schmidt R
Radiat Med. 1985 Jul-Sep;3(3):151-60.
In Hamburg, the therapy with DT-neutrons had the best curative effect on highly differentiated tumors. With the standard dose of 15.6 Gy in four weeks with fast neutrons only or--in treating tumors in radiosensitive organs such as brain and intestine--with a photon-neutron schedule, we have seen no necroses in normal tissues. The rate of medium or slight subcutaneous fibroses has been no more than 10%. The local effect on tumors in our pilot study has been better than with megavoltage therapy in invasive thyroid cancer, prostate cancer stage C, soft tissue sarcoma, and rectal carcinoma. The best results have been achieved with neutrons only, but a photon-neutron schedule may be more effective as megavoltage therapy only. With our DT-neutrons we find some indications for better results than with megavoltage therapy if we use sophisticated treatment planning and if we strictly observe the tolerance dose of the different tissues and organs. The therapeutic index of our DT-neutrons is higher than with cyclotron-produced neutrons.
在汉堡，DT 中子疗法对高分化肿瘤的疗效最佳。采用仅快中子四周 15.6 Gy 的标准剂量，或者在治疗脑和肠道等放射敏感器官的肿瘤时采用光子 - 中子治疗方案，我们未在正常组织中观察到坏死现象。中度或轻度皮下纤维化发生率不超过 10%。在我们的初步研究中，该疗法对侵袭性甲状腺癌、C 期前列腺癌、软组织肉瘤和直肠癌的局部肿瘤效果优于兆伏级放疗。仅使用中子时效果最佳，但光子 - 中子治疗方案可能与仅使用兆伏级放疗一样有效。如果我们采用精密的治疗计划并严格遵守不同组织和器官的耐受剂量，使用我们的 DT 中子治疗会比兆伏级放疗取得更好的效果。我们的 DT 中子治疗指数高于回旋加速器产生的中子。
