Oda M
Appl Neurophysiol. 1976;39(3-4):178-98.
12 Japanese cases with marked thalamus degeneration are reviewed. They are divided into 3 groups. The 4 cases of the first group showed a relatively short clinical course. Neuropathologically, the lesions of this group are selectively severe in the thalamus, and olivocerebellar atrophy is also observed. Because of the significance of the thalamic changes, this group is called 'primary thalamus degeneration'. The cases of combined system degeneration and presenile dementia, such as Pick's disease, are described in the 2nd and 3rd groups. In the thalamus, the developmentally younger, and medially and dorsolaterally located nuclei are most severely affected in all the cases. The substantia nigra, globus pallidus and cerebellar afferent systems, and occasionally the dentate nucleus, subthalamic nucleus and reticular formation, are also involved. In the cases of presenile dementia, in which the frontal and posterior parietal lobes are damaged, degenerated areas in the cerebrum and thalamus have a close relationship with each other genetically as well as in fiber connections. The clinicopathological relationship is discussed on the basis of those neuropathological findings.
本文回顾了12例伴有明显丘脑变性的日本病例。这些病例被分为3组。第一组的4例患者临床病程相对较短。神经病理学检查发现，该组病变在丘脑中具有选择性严重程度，同时还观察到橄榄小脑萎缩。由于丘脑变化的重要性，该组被称为“原发性丘脑变性”。第二组和第三组描述了合并系统变性和早老性痴呆的病例，如匹克氏病。在所有病例中，丘脑中发育较晚、位于内侧和背外侧的核团受影响最为严重。黑质、苍白球和小脑传入系统，偶尔还有齿状核、丘脑底核和网状结构也会受累。在额叶和顶叶后部受损的早老性痴呆病例中，大脑和丘脑中的退化区域在遗传和纤维连接方面彼此密切相关。基于这些神经病理学发现，对临床病理关系进行了讨论。
