一名喉咽肌张力障碍患者的丘脑橄榄体变性。

Yamamoto T, Yamashita M

Department of Neurology, Osaka Saiseikai Nakatsu Hospital, Japan.

J Neurol Neurosurg Psychiatry. 1995 Oct;59(4):438-41. doi: 10.1136/jnnp.59.4.438.

A 67 year old woman with a two year history of laryngopharyngeal dystonia, spasmodic dysphonia, and parkinsonism succumbed to Wernicke's encephalopathy and died six months later. Necropsy showed, besides Wernicke's encephalopathy, degenerative changes in selected thalamic nuclei (dorsomedial, pulvinar, and the medial geniculate bodies) and the inferior olives and numerous cerebellar torpedoes. The substantia nigra and basal ganglia were spared. Immunostaining for prion protein was negative. This patient indicated a new type of presentation of so-called pure thalamic degeneration, or more precisely thalamo-olivary degeneration.

一名67岁女性，有两年喉咽肌张力障碍、痉挛性发音困难和帕金森症病史，死于韦尼克脑病，6个月后去世。尸检显示，除韦尼克脑病变外，特定丘脑核（背内侧核、枕核和内侧膝状体）、下橄榄核有退行性改变，并有大量小脑鱼雷体。黑质和基底神经节未受累。朊蛋白免疫染色为阴性。该患者表现出一种所谓的纯丘脑变性的新型表现，或更准确地说是丘脑橄榄体变性。