忧郁症中P300的研究——与精神病性特征的相关性

A study of P300 in melancholic depression--correlation with psychotic features.

作者信息

Santosh P J, Malhotra S, Raghunathan M, Mehra Y N

机构信息

Department of Psychiatry, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

出版信息

Biol Psychiatry. 1994 Apr 1;35(7):474-9. doi: 10.1016/0006-3223(94)90046-9.

DOI:10.1016/0006-3223(94)90046-9

PMID:8018798

Abstract

The relationship between delusions and hallucinations (psychotic features) in melancholic depression and auditory P300 was studied. Forty patients with melancholic depression as per DSM-III-R were studied, 20 of whom had hallucinations and/or delusions. The 20 patients of the two groups were individually matched on age, gender, sociodemographic variables, and psychopathology (except for psychotic features). Auditory P300 obtained by the "oddball paradigm" showed that those with hallucinations and/or delusions had a significantly smaller P3 amplitude. Significant correlations between "psychotic features" and P3 amplitude was found. Implications of these findings on research, classification, and management of depression have been outlined.

摘要

对忧郁症性抑郁症中的妄想与幻觉（精神病性特征）和听觉P300之间的关系进行了研究。按照《精神疾病诊断与统计手册第三版修订本》（DSM-III-R）标准，对40例忧郁症性抑郁症患者进行了研究，其中20例有幻觉和/或妄想。两组中的20例患者在年龄、性别、社会人口统计学变量和精神病理学（除精神病性特征外）方面进行了个体匹配。通过“oddball范式”获得的听觉P300显示，有幻觉和/或妄想的患者P3波幅明显较小。发现“精神病性特征”与P3波幅之间存在显著相关性。概述了这些发现对抑郁症研究、分类和管理的意义。