Higashima M, Urata K, Kawasaki Y, Maeda Y, Sakai N, Mizukoshi C, Nagasawa T, Kamiya T, Yamaguchi N, Koshino Y
Department of Neuropsychiatry, School of Medicine, Kanazawa University, Japan.
Biol Psychiatry. 1998 Jul 15;44(2):115-20. doi: 10.1016/s0006-3223(97)00359-4.
In order to clarify the clinical significance of P300 as a biologic marker that can reflect schizophrenic symptomatology, many previous studies have evaluated the relationship of P300 with the symptoms on the basis of a positive/negative dichotomy, but yielded inconsistent conclusions. Such a dichotomy has been criticized as being too reductionistic. Recently, most studies with factor-analytic procedures have extracted some symptom factors outside this dichotomy. Therefore, it is important to examine associations of P300 with the symptom factors extracted by these statistical analyses.
In the present study, the amplitudes of P300 were measured by using an auditory oddball paradigm for 73 schizophrenics whose psychopathology was assessed with the Positive and Negative Syndrome Scale (PANSS).
The principal component analysis of the PANSS items revealed five factors labeled the thought disorder, negative, hostile/excitable, delusional/hallucinatory, and depressive factors. The score for the thought disorder factor correlated negatively with the amplitude of P300 recorded at Pz T5, and T6, but that for the other factors did not.
These findings suggest that the reduction of P300 amplitudes recorded at the midline parietal and bilateral temporoparietal regions may be one of the electrophysiologic indices representing the thought disorder clinically observed in schizophrenia.
为阐明P300作为一种可反映精神分裂症症状学的生物学标志物的临床意义，许多先前的研究基于阳性/阴性二分法评估了P300与症状之间的关系，但得出了不一致的结论。这种二分法被批评过于简化。最近，大多数采用因子分析程序的研究在这种二分法之外提取了一些症状因子。因此，研究P300与这些统计分析提取的症状因子之间的关联很重要。
在本研究中，使用听觉oddball范式对73例精神分裂症患者的P300波幅进行测量，并用阳性和阴性症状量表（PANSS）评估其精神病理学。
PANSS项目的主成分分析揭示了五个因子，分别标记为思维紊乱、阴性、敌对/易激惹、妄想/幻觉和抑郁因子。思维紊乱因子得分与Pz、T5和T6记录的P300波幅呈负相关，而其他因子得分则不然。
这些发现表明，在顶叶中线和双侧颞顶叶区域记录到的P300波幅降低可能是精神分裂症临床观察到的思维紊乱的电生理指标之一。
