Schmitt Y, Haug M, Kruse-Jarres J D
Institute of Clinical Chemistry, Katharinenhospital, Stuttgart, Fed. Rep. of Germany.
J Trace Elem Electrolytes Health Dis. 1993 Dec;7(4):223-8.
The concentrations of zinc, copper, nickel and chromium were determined in bone marrow and plasma of 37 patients suffering from non-Hodgkin-lymphomas (NHL). The results were compared with a control group of 10 patients with negative histopathologic results in bone marrow. The results demonstrate that all patients with low grade and high grade NHL have elevated trace element levels in bone marrow compared to the control group. In plasma there are also differences in the trace element levels of patients with NHL compared to the control group; the levels, however, are partly higher and lower than those of the control group. Altogether the plasma level differences are not as noticeable as those in the bone marrow. At the moment it is not yet possible to draw final conclusions from these results for the prognosis or therapy of NHL, but the study tends to show that intracellular measurement of trace elements is more reliable than intraplasmic measurement.
对37例非霍奇金淋巴瘤（NHL）患者的骨髓和血浆中的锌、铜、镍和铬浓度进行了测定。将结果与10例骨髓组织病理学结果为阴性的患者组成的对照组进行了比较。结果表明，与对照组相比，所有低级别和高级别NHL患者的骨髓中微量元素水平均升高。与对照组相比，NHL患者血浆中的微量元素水平也存在差异；然而，这些水平部分高于或低于对照组。总体而言，血浆水平差异不如骨髓中的差异明显。目前，从这些结果中还无法得出关于NHL预后或治疗的最终结论，但该研究倾向于表明，微量元素的细胞内测量比血浆内测量更可靠。
