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Effects of trace elements on immune system: results in cultured human lymphocytes.

作者信息

Borella P, Bargellini A

机构信息

Istituto di Igiene, Università degli Studi, Modena, Italy.

出版信息

J Trace Elem Electrolytes Health Dis. 1993 Dec;7(4):231-3.

PMID:8019153
Abstract

We have studied the effects of lead, cadmium and hexavalent chromium in cultured human lymphocytes. Both the proliferative response and the generation of antibodies were evaluated, and the metal accumulation in the cells was measured. Lead added in the range of human exposure caused a significant enhancement in Ig production, which was related to the Pb concentration in the cells. An inhibitory effect on blastogenesis, was detected at Cd doses found in occupationally exposed subjects. Chromium induced reductions in both blastogenesis and Ig production in relation to its capability to enter the cells.

摘要

相似文献

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