Menditto A, Morisi G, Alimonti A, Caroli S, Petrucci F, Spagnolo A, Menotti A
Laboratorio di Biochimica Clinica, Istituto Superiore di Sanità, Rome, Italy.
J Trace Elem Electrolytes Health Dis. 1993 Dec;7(4):251-3.
Serum Cu (S-Cu) and Zn (S-Zn) levels were determined in 1468 out of 1856 male subjects aged 55-75 years living in the Rome area who participated, between 1989 and 1990, in the second examination in an epidemiological (New Risk Factors) survey. Mean S-Cu and S-Zn concentrations were 15.98 mumol/l (mean +/- 2SD: 10.38-21.58 +/- mumol/l) and 13.69 mumol/l (mean +/- 2SD: 8.94-18.44 mumol/l), respectively. S-Cu levels were directly related to serum calcium levels (S-Ca), serum magnesium levels (S-Mg), daily cigarette consumption, total cholesterol and age (years). S-Zn levels were directly related to S-Ca, S-Mg and cholesterol and inversely related to age. A weak inverse linear relationship existed between S-Zn and S-Cu. After adjustment for body mass index (BMI), smoking habit, alcohol consumption and blood biochemistry in a multiple linear regression model, the relationship of S-Cu (direct) and S-Zn (inverse) to age remained statistically significant.
在居住于罗马地区、年龄在55至75岁之间的1856名男性受试者中，有1468人参与了1989年至1990年间进行的一项流行病学（新风险因素）调查的第二次检查，并测定了他们的血清铜（S-Cu）和锌（S-Zn）水平。S-Cu和S-Zn的平均浓度分别为15.98微摩尔/升（平均值±2标准差：10.38 - 21.58微摩尔/升）和13.69微摩尔/升（平均值±2标准差：8.94 - 18.44微摩尔/升）。S-Cu水平与血清钙水平（S-Ca）、血清镁水平（S-Mg）、每日吸烟量、总胆固醇和年龄（岁）直接相关。S-Zn水平与S-Ca、S-Mg和胆固醇直接相关，与年龄呈负相关。S-Zn和S-Cu之间存在微弱的负线性关系。在多元线性回归模型中对体重指数（BMI）、吸烟习惯、饮酒量和血液生化指标进行调整后，S-Cu（直接相关）和S-Zn（负相关）与年龄的关系仍具有统计学意义。
