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Full-term pregnancy with embryos from donated oocytes in a 36-year-old woman allografted for chronic myeloid leukemia.

作者信息

Rio B, Letur-Könirsch H, Ajchenbaum-Cymbalista F, Bauduer F, De Ziegler D, Pelissier C, Bernadou A, Frydman R, Zittoun R

机构信息

Service d'Hématologie, Hôtel-Dieu, Paris, France.

出版信息

Bone Marrow Transplant. 1994 Apr;13(4):487-8.

PMID:8019474
Abstract

We report the first case of full-term pregnancy arising from donated oocytes in a 36-year-old woman with chronic myeloid leukemia (CML), 6 years after allogeneic bone marrow transplantation (BMT) following total body irradiation (TBI) (12 Gy) and cyclophosphamide 120 mg/kg. The first attempt at implantation with her own cryopreserved ovocytes was unsuccessful. Thereafter, she became pregnant after donated oocyte implantation using estradiol and progesterone support replacing the defective ovarian function. The baby was normal. Unfortunately, 6 months later, she relapsed in chronic phase of CML.

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