Abir R, Fisch B, Raz A, Nitke S, Ben-Rafael Z
Department of Obstetrics and Gynecology, Rabin Medical Center, Petah Tikva, Israel.
J Assist Reprod Genet. 1998 Sep;15(8):469-77. doi: 10.1023/a:1022578303272.
Anticancer treatment causes ovarian failure.
Some hormones may have a protective effect on the ovary. Cryopreservation (freezing) of oocytes has had very limited success, and therefore, currently its use before chemotherapy is not a feasible option. However, cryopreservation of embryos is possible. Another solution is oocyte donation followed by in vitro fertilization (IVF).
Ovarian cortical slices containing primordial follicles have been cryopreserved successfully. To restore fertility, cryopreserved-thawed tissue taken from cancer patients before therapy could be replanted after recovery. The possible risk of malignancy restoration could be eliminated by obtaining unilaminar follicles from cryopreserved-thawed tissue and growing them in vitro, followed by routine IVF.
Although women who undergo chemotherapy face limited options for fertility preservation, intensive studies in cryopreservation and in vitro maturation of follicles harbor hope for brighter prospects in the future.
抗癌治疗会导致卵巢功能衰竭。
某些激素可能对卵巢有保护作用。卵母细胞冷冻保存（冷冻）的成功率非常有限，因此目前在化疗前使用它不是一个可行的选择。然而，胚胎冷冻保存是可行的。另一种解决办法是卵母细胞捐赠后进行体外受精（IVF）。
含有原始卵泡的卵巢皮质切片已成功冷冻保存。为恢复生育能力，治疗前从癌症患者身上取出的冷冻解冻组织在康复后可以重新植入。通过从冷冻解冻组织中获取单层卵泡并在体外培养，然后进行常规体外受精，可以消除恶性肿瘤恢复的潜在风险。
尽管接受化疗的女性在生育力保存方面选择有限，但在卵泡冷冻保存和体外成熟方面的深入研究为未来带来了更光明的前景。
