Samuelsson A, Fuchs T, Simonsson B, Björkholm M
Department of Medicine, Karolinska Hospital, Stockholm, Sweden.
Bone Marrow Transplant. 1993 Dec;12(6):659-60.
We report a successful pregnancy in a woman who at the age of 28 years received total body irradiation (TBI; 7.5 Gy) and high-dose chemotherapy prior to autografting of purged bone marrow for acute lymphoblastic leukemia. Four years after transplantation she delivered a healthy girl. Only five previous cases of successful pregnancies are described in the literature after conditioning regimens including TBI. This case shows that restored ovarian function is possible after TBI in spite of prolonged exposure to chemotherapeutic agents during induction and consolidation therapy and relatively high age at the time of transplantation.
我们报告了一例成功妊娠的病例。该女性28岁，在为急性淋巴细胞白血病进行净化骨髓自体移植之前接受了全身照射（TBI；7.5 Gy）和高剂量化疗。移植四年后，她生下了一个健康的女孩。文献中仅描述了另外五例在包括TBI的预处理方案后成功妊娠的病例。该病例表明，尽管在诱导和巩固治疗期间长时间接触化疗药物且移植时年龄相对较大，但TBI后卵巢功能仍有可能恢复。
