Chiariello L, Penta de Peppo A, Pierri M D
Cattedra di Cardiochirurgia, Università degli Studi Tor Vergata, Roma.
Cardiologia. 1993 Dec;38(12 Suppl 1):119-28.
Unstable angina is a serious condition with high risk of early coronary events; coronary revascularization in these patients gives good results but carries higher operative risk than in stable angina patients. Full medical therapy with antiischemic agents may be effective in controlling symptoms and preventing death and is therefore the first treatment of choice; as in stable angina, further treatment is indicated in stabilized patients according to non invasive tests results and coronary angiograms. Non responsive unstable patients have a poor outcome and are candidates for revascularization: angioplasty may be preferred in single or double vessel disease and bypass operation in multivessel disease. However, surgical revascularization in single and double vessel disease with critical proximal stenosis of a large anterior descending gives optimal results in our experience and may be the treatment of choice also in these patients. Because of the higher operative risk in multivessel disease in unstable ischemia, a combined procedure with angioplasty of the "culprit" lesion followed by full revascularization at a later time may be a more favourable option in some patients with multivessel disease.
不稳定型心绞痛是一种严重疾病,早期发生冠状动脉事件的风险很高;这些患者进行冠状动脉血运重建术效果良好,但手术风险高于稳定型心绞痛患者。使用抗缺血药物进行充分的药物治疗可能对控制症状和预防死亡有效,因此是首选的初始治疗方法;与稳定型心绞痛一样,根据无创检查结果和冠状动脉造影,对病情稳定的患者进行进一步治疗。药物治疗无反应的不稳定型患者预后较差,是血运重建术的候选对象:单支或双支血管病变时血管成形术可能更受青睐,多支血管病变时则选择搭桥手术。然而,根据我们的经验,单支和双支血管病变且前降支近端严重狭窄时进行外科血运重建术可取得最佳效果,在这些患者中也可能是首选治疗方法。由于不稳定型缺血多支血管病变的手术风险较高,对于一些多支血管病变患者,先对“罪犯”病变进行血管成形术,随后择期进行完全血运重建术的联合手术可能是更有利的选择。