Di Renzi P, Gaudio C, Di Cesare E, Tanzilli G, Passariello R, Campa P P
II Cattedra di Radiologia, Università degli Studi La Sapienza, Roma.
Cardiologia. 1993 Dec;38(12 Suppl 1):21-6.
Atherosclerosis is the disease with the most important social impact in terms of cost and human life. Its study in the prevention and cure of its consequences needs integration using many imaging modalities, and magnetic resonance presents advantages due to its particular characteristics. The Authors make an overview of its indications and potential applications in the assessment of atherosclerotic disease. In vitro studies have demonstrated that it is possible to evaluate the normal and abnormal components of vessel walls by means of magnetic resonance imaging (MRI) as well as fatty deposition and intraplaque hemorrhage. On the other hand, in the in vivo studies, despite the impossibility to make a too fine structural analysis of the vessel wall, MRI allows to easily discriminate between blood flow and parietal wall. This is of great importance in the study concerning arterial aneurysms, that represent a consequence of atherosclerotic disease. Information as the presence, the site, the extension, the collateral vessel involvement and, finally, the presence or absence of dissection are all obtainable by using MRI. In the early 1990's magnetic resonance angiography (MRA) was developed and is now used in clinical practice. By means of this new application of MRI there is the possibility of increasing the non invasive screening of atherosclerosis especially in some body districts. The evaluation of the plaque obtainable by the combined use of MRA and ultrasound studies allows to decrease the employment of traditional and digital angiography. If, as studies predict, we will able to obtain coronary angiograms in the near future, there will be a further increase in the non invasive evaluation and in the prevention of atherosclerotic disease.
就成本和人类生命而言,动脉粥样硬化是具有最重要社会影响的疾病。对其后果的预防和治疗研究需要整合多种成像方式,而磁共振成像因其特殊特性具有优势。作者概述了其在动脉粥样硬化疾病评估中的适应证和潜在应用。体外研究表明,通过磁共振成像(MRI)可以评估血管壁的正常和异常成分以及脂肪沉积和斑块内出血。另一方面,在体内研究中,尽管无法对血管壁进行过于精细的结构分析,但MRI能够轻松区分血流和血管壁。这在有关动脉瘤的研究中非常重要,动脉瘤是动脉粥样硬化疾病的一种后果。通过使用MRI可以获取诸如动脉瘤的存在、位置、范围、侧支血管受累情况以及最终是否存在夹层等信息。20世纪90年代初,磁共振血管造影(MRA)得以开发,如今已应用于临床实践。通过MRI的这种新应用,有可能增加动脉粥样硬化的无创筛查,尤其是在某些身体部位。联合使用MRA和超声检查对斑块进行评估,可以减少传统血管造影和数字血管造影的使用。如果正如研究预测的那样,在不久的将来我们能够获得冠状动脉造影图像,那么无创评估和动脉粥样硬化疾病的预防将会进一步增加。