Anttila S, Hirvonen A, Husgafvel-Pursiainen K, Karjalainen A, Nurminen T, Vainio H
Institute of Occupational Health, Helsinki, Finland.
Carcinogenesis. 1994 Jun;15(6):1133-5. doi: 10.1093/carcin/15.6.1133.
The combinations of the CYP1A1 inducibility and GSTM1 polymorphism have been investigated in relation to the histological type and peripheral or bronchial location of lung cancer in 54 surgically treated, current smoker lung cancer patients. The induced CYP1A1 was detected in 46 patients (85%) and the homozygous GSTM1 null genotype in 32 patients (59%). The role of CYP1A1 inducibility was found to be more important than that of GSTM1 polymorphism, because the non-inducible CYP1A1 was associated solely with bronchial tumours (P = 0.001), mainly squamous cell carcinomas. In patients with inducible CYP1A1, the expressing GSTM1 gene appeared to have a protective effect against contracting bronchial lung cancer, since 88% (14/16) of the lung tumours in this patient group were peripheral, whereas almost equal numbers of peripheral and bronchial tumours were observed in those patients lacking the gene (P = 0.037).
在54例接受手术治疗的现吸烟者肺癌患者中，研究了CYP1A1诱导性和GSTM1基因多态性的组合与肺癌组织学类型及外周或支气管位置的关系。46例患者（85%）检测到诱导型CYP1A1，32例患者（59%）检测到纯合子GSTM1缺失基因型。发现CYP1A1诱导性的作用比GSTM1基因多态性更重要，因为非诱导型CYP1A1仅与支气管肿瘤相关（P = 0.001），主要是鳞状细胞癌。在CYP1A1可诱导的患者中，表达GSTM1基因似乎对患支气管肺癌有保护作用，因为该患者组中88%（14/16）的肺肿瘤为外周型，而在缺乏该基因的患者中观察到外周型和支气管型肿瘤的数量几乎相等（P = 0.037）。
