Pereira M L, Silva A, Tracana R, Carvalho G S
Department of Biology, University of Aveiro, Portugal.
Cytobios. 1994;77(309):73-80.
Stainless steel type AISI 316L is widely used in orthopaedic surgery. The toxic effects of its corrosion products on the morphology of mouse seminiferous cells were investigated. Chemical elements from stainless steel were released into a physiological medium using an electrochemical method. This metallic solution was injected subcutaneously into male Charles River mice at 72 h intervals for 10 days. Electron microscopic observations of seminiferous tubule thin sections showed that the metallic suspension caused tissue vacuolation, cell degeneration, and multinucleated cell formation. This apparent tissue toxicity induced by stainless steel corrosion products suggests that long term implantation of such biomaterials may impair spermatogenesis.
AISI 316L型不锈钢在整形外科手术中广泛使用。研究了其腐蚀产物对小鼠生精细胞形态的毒性作用。采用电化学方法将不锈钢中的化学元素释放到生理介质中。将这种金属溶液每隔72小时皮下注射到雄性查尔斯河小鼠体内，持续10天。对生精小管薄片的电子显微镜观察表明，金属悬浮液导致组织空泡化、细胞变性和多核细胞形成。不锈钢腐蚀产物引起的这种明显的组织毒性表明，长期植入此类生物材料可能会损害精子发生。
