Yemma J J, Berk M P
Department of Biology, Youngstown State University, Ohio 44555.
Cytobios. 1994;77(310):147-58.
The prevalence of immunologically suppressed patients, including those infected with the AIDS virus, with cancer, and those having had transplant surgery to name a few, has provided an avenue for the rapid proliferation among these patients of the virulent yeast Candida albicans. Previous studies have determined that a potent toxin is produced by C. albicans which may cause extensive tissue damage. The extent of the tissue damage has never been determined, neither has the mechanism been explained. The present work shows that intraperitoneal inoculation of C. albicans produces numerous tumour-like lesions and abscesses on the major organs of experimental laboratory rats. The results demonstrate that damage is caused by the initial release of lysosomal enzymes by the affected tissues.
免疫抑制患者的数量不断增加，其中包括感染艾滋病病毒的患者、癌症患者以及接受过移植手术的患者等等，这为毒性极强的白色念珠菌在这些患者中的迅速增殖提供了途径。先前的研究已确定，白色念珠菌会产生一种强效毒素，这种毒素可能会导致广泛的组织损伤。然而，组织损伤的程度从未得到确定，其机制也未得到解释。目前的研究表明，腹腔接种白色念珠菌会在实验大鼠的主要器官上产生大量肿瘤样病变和脓肿。结果表明，损伤是由受影响组织最初释放溶酶体酶引起的。
