Mathew S, Murty V V, Cheifetz S, George D, Massagué J, Chaganti R S
Cell Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10021.
Genomics. 1994 Mar 1;20(1):114-5. doi: 10.1006/geno.1994.1134.
In this study, we map the chromosomal position of the gene that encodes the type II receptor of TGF-beta (HGM symbol TGFBR2), a multifunctional regulator of cell proliferation and differentiation. Using a full-length cDNA and a genomic probe in Southern blot analysis of a human x rodent somatic cell hybrid panel and by direct fluorescence in situ hybridization to normal metaphase chromosomes, we show that the TGFBR2 gene maps to 3p22.
在本研究中，我们绘制了编码转化生长因子β（TGF-β）II型受体（人类基因组图谱符号为TGFBR2）基因的染色体位置，TGF-β是一种细胞增殖和分化的多功能调节因子。通过使用全长cDNA和基因组探针，对人类x啮齿动物体细胞杂交细胞系进行Southern印迹分析，并直接对正常中期染色体进行荧光原位杂交，我们发现TGFBR2基因定位于3p22。
