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卡瓦皮肤病变

Kava dermopathy.

作者信息

Norton S A, Ruze P

机构信息

Department of Medicine, Tripler Army Medical Center, Honolulu, HI 96859.

出版信息

J Am Acad Dermatol. 1994 Jul;31(1):89-97. doi: 10.1016/s0190-9622(94)70142-3.

Abstract

Kava is a psychoactive beverage used ceremonially for thousands of years by Pacific Islanders. Kava is made from the root of the pepper plant, Piper methysticum, found in Polynesia, Melanesia, and Micronesia. The beverage is a nonfermented depressant with complex neuropharmacologic properties that causes a tranquil state of intoxication. Kava also affects the skin, causing a peculiar scaly eruption. The cutaneous effects were first reported by members of Captain James Cook's Pacific expeditions, but they have never been described in dermatologic literature. Heavy kava drinkers acquire a reversible ichthyosiform eruption, kava dermopathy. The cause is unknown but may relate to interference with cholesterol metabolism. Today kava is used across the Pacific in both traditional ceremonies and informal social events. In Western nations, kava is sold as a relaxant by health food stores. This article explores the history of kava dermopathy from Cook's early reports to its presence today.

摘要

卡瓦是一种具有精神活性的饮品,数千年来一直被太平洋岛民用于仪式场合。卡瓦由胡椒科植物卡瓦胡椒的根制成,这种植物生长在波利尼西亚、美拉尼西亚和密克罗尼西亚。这种饮品是一种非发酵的抑制剂,具有复杂的神经药理学特性,会导致一种宁静的沉醉状态。卡瓦还会影响皮肤,引起一种特殊的鳞状皮疹。这种皮肤效应最早是由詹姆斯·库克船长太平洋探险队的成员报告的,但在皮肤病学文献中从未有过描述。大量饮用卡瓦的人会出现一种可逆的鱼鳞病样皮疹,即卡瓦皮肤病。其病因不明,但可能与干扰胆固醇代谢有关。如今,卡瓦在整个太平洋地区的传统仪式和非正式社交活动中都有使用。在西方国家,卡瓦作为一种放松剂在健康食品商店出售。本文探讨了从库克早期报告到如今卡瓦皮肤病的历史。

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