Starkstein S E, Migliorelli R, Tesón A, Sabe L, Vázquez S, Turjanski M, Robinson R G, Leiguarda R
Department of Behavioural Neurology, Raúl Carrea Institute of Neurological Research, Buenos Aires, Argentina.
J Neurol Neurosurg Psychiatry. 1994 Jul;57(7):790-6. doi: 10.1136/jnnp.57.7.790.
Eight patients with a clinical diagnosis of probable Alzheimer's disease, eight patients with the clinical diagnosis of frontal lobe dementia, and eight controls were examined with single photon emission tomography (SPECT) using 99Tc-HMPAO. Patients with Alzheimer's disease and those with frontal lobe dementia met DSM-III-R criteria for mild dementia and were in the early stages of the illness. Compared with patients with Alzheimer's disease, the group with frontal lobe dementia had significantly lower blood flow in the frontal lobes (dorsolateral and orbital), the anterior temporal cortex, and the basal ganglia. Within the frontal lobe dementia group, blood flow was significantly lower in the orbital than in the dorsal frontal cortex, and in the anterior temporal than in the dorsal temporal cortex. The present study shows the specificity of changes in regional cerebral blood flow in the diagnosis of different types of dementia, and supports the importance of orbitofrontal, anterior temporal, and basal ganglia dysfunction in the production of the psychiatric syndrome of frontal lobe dementia.
对8例临床诊断为可能的阿尔茨海默病患者、8例临床诊断为额叶痴呆患者和8例对照者使用99Tc-HMPAO进行单光子发射断层扫描（SPECT）检查。阿尔茨海默病患者和额叶痴呆患者符合DSM-III-R轻度痴呆标准，且处于疾病早期阶段。与阿尔茨海默病患者相比，额叶痴呆组在额叶（背外侧和眶部）、颞叶前部皮质和基底神经节的血流明显较低。在额叶痴呆组内，眶部的血流明显低于额叶背侧皮质，颞叶前部的血流明显低于颞叶背侧皮质。本研究显示了不同类型痴呆诊断中局部脑血流变化的特异性，并支持眶额、颞叶前部和基底神经节功能障碍在额叶痴呆精神综合征产生中的重要性。
