Kamo H, McGeer P L, Harrop R, McGeer E G, Calne D B, Martin W R, Pate B D
Neurology. 1987 Mar;37(3):439-45. doi: 10.1212/wnl.37.3.439.
PET using 18F-2-fluoro-2-deoxyglucose was carried out on a case of Pick's disease established by necropsy. A sharply decreased cortical metabolic rate for glucose was obtained in specific gyri, especially in the frontal lobes, where there was extensive gliosis and neuronal loss. More moderate decreases were found in areas with numerous Pick bodies and inflated neurons but less gliosis. The PET pattern was sufficiently distinctive to suggest that it might be possible to distinguish Pick's from Alzheimer's disease premortem.
对一例经尸检确诊的匹克氏病患者进行了使用18F - 2 - 氟 - 2 - 脱氧葡萄糖的正电子发射断层扫描（PET）。在特定脑回，尤其是额叶，发现皮质葡萄糖代谢率急剧下降，额叶存在广泛的神经胶质增生和神经元丢失。在有大量匹克小体和肿胀神经元但神经胶质增生较少的区域，代谢率下降较为中等。PET图像模式具有足够的特异性，提示有可能在生前将匹克氏病与阿尔茨海默病区分开来。
