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Crosslinking and cleavage of pBR322 DNA photosensitized by 7-methylpyrido[3,4-c]psoralen.

作者信息

Chen X, Kagan J

机构信息

Department of Chemistry, University of Illinois, Chicago 60607-7061.

出版信息

J Photochem Photobiol B. 1994 Apr;23(1):27-33. doi: 10.1016/1011-1344(93)06979-d.

DOI:10.1016/1011-1344(93)06979-d
PMID:8021747
Abstract

7-Methylpyrido[3,4-c]psoralen (7-MPP) had been designed to be a monofunctional sensitizer in which the pyrone double bond, being engaged in a pyridine ring, would be incapable of participating in the formation of a cyclobutane ring with a DNA component. However, one example of photosensitization of thymine-thymine dimer formation in DNA by 7-MPP had been reported. This paper proves that 7-MPP can sensitize interstrand crosslinks in pBR322 DNA. It also proves that 7-MPP photosensitizes double strand cleavage reactions in the DNA with an unusually large degree of site selectivity.

摘要

相似文献

1
Crosslinking and cleavage of pBR322 DNA photosensitized by 7-methylpyrido[3,4-c]psoralen.
J Photochem Photobiol B. 1994 Apr;23(1):27-33. doi: 10.1016/1011-1344(93)06979-d.
2
Sites of preferred interaction between double-stranded pBR322 DNA and 7-methylpyrido[3,4-c]psoralen.双链pBR322 DNA与7-甲基吡啶并[3,4-c]补骨脂素之间优先相互作用的位点
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Mutagenic SOS repair of site-specific psoralen damage in plasmid pBR322.质粒pBR322中位点特异性补骨脂素损伤的诱变SOS修复
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Photosensitized cross-linking and cleavage of pBR322 and M13 DNA: comparison of 4,4',6-trimethylangelicin and 3-carbethoxypsoralen.补骨脂素对pBR322和M13 DNA的光敏交联与切割：4,4',6-三甲基补骨脂素与3-乙氧羰基补骨脂素的比较
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Measurement of interstrand cross-link frequency and distance between interruptions in DNA exposed to 4,5',8-trimethylpsoralen and near-ultraviolet light.
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Photochem Photobiol. 1996 Aug;64(2):349-55. doi: 10.1111/j.1751-1097.1996.tb02470.x.

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