体外和体内接触葡萄糖酸氯己定对白色念珠菌体外黏附糖尿病和非糖尿病受试者颊黏膜上皮细胞的影响。
The effect of exposure to chlorhexidine gluconate in vitro and in vivo on in vitro adhesion of Candida albicans to buccal epithelial cells from diabetic and non-diabetic subjects.
作者信息
Darwazeh A M, Lamey P J, MacFarlane T W, McCuish A C
机构信息
Department of Oral Sciences, Jordan University of Science and Technology.
出版信息
J Oral Pathol Med. 1994 Mar;23(3):130-2. doi: 10.1111/j.1600-0714.1994.tb01100.x.
The effect of 0.2% chlorhexidine gluconate on in vitro adhesion of Candida albicans to buccal epithelial cells (BEC) was studied in 12 healthy subjects and 12 patients with diabetes mellitus. Exposure of BEC for one minute with 0.2% chlorhexidine gluconate in vitro, or by rinsing the mouth in vivo, resulted in a significant reduction in candidal adhesion to BEC in both diabetic and non-diabetic subjects and between both groups. In addition to the known fungicidal effect of chlorhexidine, it also reduces Candida albicans adhesion to oral mucosal cells, a factor of importance in the establishment of candidal infection.
在12名健康受试者和12名糖尿病患者中研究了0.2%葡萄糖酸氯己定对白色念珠菌体外黏附于颊黏膜上皮细胞（BEC）的影响。体外将BEC暴露于0.2%葡萄糖酸氯己定1分钟，或体内漱口，均导致糖尿病和非糖尿病受试者以及两组之间念珠菌对BEC的黏附显著减少。除了氯己定已知的杀菌作用外，它还能减少白色念珠菌对口腔黏膜细胞的黏附，这是念珠菌感染发生过程中的一个重要因素。
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