Darwazeh A M, MacFarlane T W, Lamey P J
Department of Oral Medicine and Periodontology, Faculty of Dentistry, Jordan University of Science and Technology, Irbid, Jordan.
J Oral Pathol Med. 1997 May;26(5):233-6. doi: 10.1111/j.1600-0714.1997.tb01229.x.
Buccal epithelial cells (BEC) from 12 patients with diabetes mellitus and 12 age- and sex-matched non-diabetic subjects were tested in vitro for adhesion of Candida albicans following exposure to nystatin both in vitro and in vivo. Adhesion was significantly reduced (P < 0.002) to cells from both the diabetic and non-diabetic subjects after in vitro exposure to nystatin, but the reduction in adhesion was variable (5.0-50.7% in control subjects and 0.5-48.4% in diabetic subjects) and equivalent between the two groups. In vivo exposure to nystatin produced no overall significant reduction in candidal adhesion to cells from either diabetic or control subjects.
对12名糖尿病患者以及12名年龄和性别匹配的非糖尿病受试者的颊黏膜上皮细胞（BEC）进行体外测试，检测白色念珠菌在体内和体外接触制霉菌素后的黏附情况。体外接触制霉菌素后，糖尿病患者和非糖尿病受试者细胞上的黏附均显著减少（P < 0.002），但黏附减少情况存在差异（对照组为5.0 - 50.7%，糖尿病组为0.5 - 48.4%），且两组间相当。体内接触制霉菌素后，糖尿病患者或对照组受试者细胞上念珠菌的黏附总体上没有显著减少。
