Dubbert P M, Martin J E, Cushman W C, Meydrech E F, Carroll R G
Department of Veterans Affairs Medical Centre, Jackson, MS.
J Hum Hypertens. 1994 Apr;8(4):265-72.
The effects of a ten week endurance exercise training programme on blood pressure and associated metabolic and quality of life variables were examined in 28 unmedicated mildly hypertensive men (21-54 years of age). At baseline, BP averaged 138.8/94.8 mmHg, body mass index averaged 27.9 and percentage body fat averaged 29%. The average reduction in BP of 11.4/9.8 mmHg (P = 0.0001) was accompanied by decreases in plasma renin activity of 1.82 ng/ml/h (P = 0.001) and in total plasma catecholamines of 77.9 pg/ml (P = 0.05). Percentage body fat decreased 1.3% (P = 0.02) and work capacity increased 1.2 METS (P = 0.002). There were no significant changes in body weight or plasma lipids, cortisol, insulin or urinary electrolyte excretion. Changes in SBP were correlated significantly with change in plasma renin activity (r = 0.38, P = 0.05). Favourable changes were also observed in mood (P = 0.04) and in one measure of type A behaviour (P = 0.04). None of the participants sustained an injury. We conclude that reduction of BP with endurance exercise training in these mildly hypertensive men was primarily associated with reduced plasma renin activity and did not adversely affect quality of life.
在28名未接受药物治疗的轻度高血压男性（21 - 54岁）中，研究了为期十周的耐力运动训练计划对血压以及相关代谢和生活质量变量的影响。基线时，血压平均为138.8/94.8 mmHg，体重指数平均为27.9，体脂百分比平均为29%。血压平均降低11.4/9.8 mmHg（P = 0.0001），同时血浆肾素活性降低1.82 ng/ml/h（P = 0.001），血浆总儿茶酚胺降低77.9 pg/ml（P = 0.05）。体脂百分比下降1.3%（P = 0.02），工作能力增加1.2 METS（P = 0.002）。体重、血浆脂质、皮质醇、胰岛素或尿电解质排泄均无显著变化。收缩压的变化与血浆肾素活性的变化显著相关（r = 0.38，P = 0.05）。在情绪（P = 0.04）和一项A型行为指标（P = 0.04）方面也观察到了有利变化。没有参与者受伤。我们得出结论，这些轻度高血压男性通过耐力运动训练降低血压主要与血浆肾素活性降低有关，且对生活质量没有不利影响。
