Sieg S, Muro-Cacho C, Robertson S, Huang Y, Kaplan D
Department of Pathology, Case Western Reserve University, Cleveland, OH 44106-4943.
Proc Natl Acad Sci U S A. 1994 Jul 5;91(14):6293-7. doi: 10.1073/pnas.91.14.6293.
Human parainfluenza virus type 3 (HPIV3) is a major cause of disease in newborns and infants. It also has a striking potential to reinfect individuals throughout their lives, suggesting that HPIV3 does not induce lifelong immunity; however, the operative mechanism for the failure to prevent reinfection is not known. We have assessed the potential of the virus to infect nontransformed human T lymphocytes and have found that T cells are readily infected by the virus. Productive infection requires activation of the T cells and results in a marked inhibition of proliferation. Furthermore, our results indicate that exposure to the virus, even without overt expression of viral proteins as detected by immunohistology, profoundly alters the functional capacity of the T cells. The capacity of the virus to regulate T-lymphocyte function may play an important role in the failure of the virus to induce lifelong immunity.
人副流感病毒3型（HPIV3）是新生儿和婴儿患病的主要原因。它还具有在个体一生中反复感染的显著可能性，这表明HPIV3不会诱导终身免疫；然而，未能预防再次感染的作用机制尚不清楚。我们评估了该病毒感染未转化的人T淋巴细胞的可能性，发现T细胞很容易被该病毒感染。有效感染需要激活T细胞，并导致增殖受到显著抑制。此外，我们的结果表明，即使通过免疫组织学检测未发现病毒蛋白的明显表达，接触该病毒也会深刻改变T细胞的功能能力。该病毒调节T淋巴细胞功能的能力可能在其无法诱导终身免疫中起重要作用。
