Otterness I G, Milici A J, Bliven M L
Department of Immunology and Infectious Diseases, Pfizer Central Research, Groton, CT 06340.
Agents Actions. 1993 Nov;40(3-4):224-7. doi: 10.1007/BF01984066.
Mobility is impaired during arthritis. In order to study the causes of the mobility impairment, we have examined hamsters with a LPS arthritis in which running is inhibited over a 4-5 day period. Parameters have been examined to determine which correlate with running impairment. Knee diameter, as well as cell infiltration into the surrounding synovial tissue and the accompanying edema, failed to resolve by the time normal mobility was reestablished. Other factors must be primary determinants of mobility.
关节炎期间活动能力受损。为了研究活动能力受损的原因，我们检查了患有脂多糖诱导关节炎的仓鼠，在4-5天的时间里它们的奔跑受到抑制。已对各项参数进行检查，以确定哪些参数与奔跑障碍相关。当恢复正常活动能力时，膝关节直径以及周围滑膜组织中的细胞浸润和随之而来的水肿仍未消退。其他因素必定是活动能力的主要决定因素。
