Friedman H D, Hutchison R E, Smith J R, Gonchoroff N J, Stein C K, Poiesz B J
Department of Pathology and Laboratory Medicine, Syracuse, NY 13210.
Arch Pathol Lab Med. 1994 Jul;118(7):722-7.
Polylobated lymphoma is a morphologic variant of malignant lymphoma characterized by large pleomorphic neoplastic cells with polylobated nuclei. We report an unusual case in a 57-year-old man with a 9-year history of an antecedent low-grade peripheral T-cell lymphoma with dermal involvement. The polylobated lymphoma expressed the CD2, 8, 45, and DR surface antigens and had a clonally rearranged T-cell receptor beta-chain gene. The DNA content analysis indicated that most of the neoplasm was DNA diploid and tetraploid, with a high S phase. Cytogenetic analysis demonstrated the presence of a clone with an abnormal karyotype 45, X, -Y, -1, -10, -10, -17, -19, +5 mar. Serology and polymerase chain reaction analysis showed no evidence of retroviral infection (human immunodeficiency virus types 1 and 2 and human T-cell lymphotropic virus types I and II). We review the literature on polylobated T-cell lymphoma.
多叶状淋巴瘤是恶性淋巴瘤的一种形态学变异型，其特征为具有多叶状核的大的多形性肿瘤细胞。我们报告了一例不寻常的病例，患者为一名57岁男性，有9年的前期低度外周T细胞淋巴瘤伴皮肤受累病史。多叶状淋巴瘤表达CD2、8、45和DR表面抗原，并且具有克隆性重排的T细胞受体β链基因。DNA含量分析表明，大多数肿瘤为DNA二倍体和四倍体，S期比例高。细胞遗传学分析显示存在一个核型异常的克隆，即45,X,-Y,-1,-10,-10,-17,-19,+5 mar。血清学和聚合酶链反应分析未显示逆转录病毒感染的证据（1型和2型人类免疫缺陷病毒以及1型和2型人类T细胞嗜淋巴细胞病毒）。我们回顾了关于多叶状T细胞淋巴瘤的文献。
