Rudd C E, Janssen O, Cai Y C, da Silva A J, Raab M, Prasad K V
Division of Tumor Immunology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115.
Immunol Today. 1994 May;15(5):225-34. doi: 10.1016/0167-5699(94)90248-8.
A central question in T-cell immunity concerns the nature of intracellular signaling from the antigen receptor, the CD4/CD8 co-receptors and the CD28 antigen. Since the original discovery that T-cell receptors such as CD4 can interact with intracellular protein-tyrosine kinases such as p56lck, remarkable progress has been made in deciphering the signaling pathways that control T-cell growth and immune function. Here, Christopher Rudd and colleagues examine the role of protein-tyrosine kinases, SH2/SH3 domains and lipid kinases in the generation of signals from the TCR zeta/CD3 complex and the CD28 antigen.
T细胞免疫中的一个核心问题涉及来自抗原受体、CD4/CD8共受体以及CD28抗原的细胞内信号传导的本质。自从最初发现诸如CD4之类的T细胞受体能够与诸如p56lck之类的细胞内蛋白酪氨酸激酶相互作用以来，在破解控制T细胞生长和免疫功能的信号传导途径方面已经取得了显著进展。在此，克里斯托弗·拉德及其同事研究了蛋白酪氨酸激酶、SH2/SH3结构域以及脂质激酶在由TCR ζ链/CD3复合物和CD28抗原产生信号过程中的作用。
