黑腹果蝇X染色体上的细胞色素P450基因簇。
Cluster of cytochrome P450 genes on the X chromosome of Drosophila melanogaster.
作者信息
Frolov M V, Alatortsev V E
机构信息
Institute of Molecular Genetics, Moscow, Russia.
出版信息
DNA Cell Biol. 1994 Jun;13(6):663-8. doi: 10.1089/dna.1994.13.663.
A new cytochrome P450 gene was found within the wap1-prune genetic region of the Drosophila melanogaster X chromosome. It encodes a putative cytochrome P450 of subfamily 4D and has been designated CYP4D2. CYP4D2 has a complex exon-intron structure. Both the heme-binding motif and a region diagnostic for family 4 are not interrupted by introns. CYP4D2 lies 20 kb proximal to the previously described CYP4D1 gene (Gandhi et al., 1992). In addition to CYP4D1 and CYP4D2, two other DNA fragments homologous to P450 genes are detected within the wap1-prune region.
在果蝇X染色体的wap1 - prune遗传区域内发现了一个新的细胞色素P450基因。它编码一个假定的4D亚家族细胞色素P450，并被命名为CYP4D2。CYP4D2具有复杂的外显子 - 内含子结构。血红素结合基序和4家族的诊断区域均未被内含子打断。CYP4D2位于先前描述的CYP4D1基因（甘地等人，1992年）近端20 kb处。除了CYP4D1和CYP4D2之外，在wap1 - prune区域内还检测到另外两个与P450基因同源的DNA片段。
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