Loughnan B A, McHale S P, Welsh K R, Hall G M
Department of Anaesthesia, Northwick Park Hospital, Harrow, Middlesex.
Br J Anaesth. 1994 Jun;72(6):620-3. doi: 10.1093/bja/72.6.620.
We have examined the effects of lumbar extradural administration of 1% etidocaine 10 ml on somatosensory evoked potentials to posterior tibial nerve stimulation measured in the cervical extradural space. Eight patients, anaesthetized with propofol and nitrous oxide, were studied before hysterectomy and a control group received a similar anaesthetic and 0.9% sodium chloride solution 10 ml in the lumbar extradural space. Etidocaine decreased significantly overall amplitude of the evoked potentials and the amplitudes of all peaks, between 30 and 50 min after extradural injection. The effects of etidocaine on spinal cord conduction were greater than those found previously for lignocaine and bupivacaine, suggesting that it is the local analgesic of choice for inhibiting afferent conduction.
我们研究了在腰段硬膜外给予10毫升1%依替卡因对在颈段硬膜外间隙测量的胫后神经刺激体感诱发电位的影响。八名用丙泊酚和氧化亚氮麻醉的患者在子宫切除术前接受了研究，一个对照组接受了类似的麻醉，并在腰段硬膜外间隙注射10毫升0.9%氯化钠溶液。依替卡因在硬膜外注射后30至50分钟之间显著降低了诱发电位的总体幅度以及所有波峰的幅度。依替卡因对脊髓传导的影响大于先前发现的利多卡因和布比卡因，表明它是抑制传入传导的首选局部镇痛药。
