Tadakuma T
Department of Microbiology, Keio University School of Medicine, Japan.
Hum Cell. 1994 Mar;7(1):20-6.
T cells are responsible for the discrimination of self and nonself. To acquire such activities, however, T cells must encounter two selections in the thymus, namely positive and negative selections. Recent data from in vivo and in vitro experiments strongly indicated that apoptosis is involved in these selections, especially in the elimination of the cells reactive to self antigens. This article briefly reviewed the roles of apoptosis in the development of T cells in the thymus.
T细胞负责区分自身和非自身。然而，为了获得这种功能，T细胞必须在胸腺中经历两种选择，即阳性选择和阴性选择。来自体内和体外实验的最新数据有力地表明，细胞凋亡参与了这些选择，尤其是在清除对自身抗原产生反应的细胞方面。本文简要回顾了细胞凋亡在胸腺T细胞发育中的作用。
