与上次足月妊娠后的间隔时间相关的乳腺癌风险。
Risk of breast cancer in relation to the interval since last full term pregnancy.
作者信息
Cummings P, Stanford J L, Daling J R, Weiss N S, McKnight B
机构信息
University of Washington School of Public Health and Community Medicine, Seattle 98112.
出版信息
BMJ. 1994 Jun 25;308(6945):1672-4. doi: 10.1136/bmj.308.6945.1672.
OBJECTIVE
To examine whether the risk of breast cancer is increased by a recent term pregnancy.
DESIGN
Population based case-control study.
SETTING
Eight areas in the United States.
SUBJECTS
Cases were 2279 multiparous women residents of the eight areas aged 25-49 who were diagnosed as having breast cancer during 1980-2. Controls were 2357 multiparous women selected from the same areas by random digit dialing.
MAIN OUTCOME MEASURE
Relative risk of developing breast cancer according to the time interval since last full term pregnancy.
RESULTS
The distribution of intervals since the last term pregnancy was similar in cases and controls. Adjusted for age, parity, and age at first term pregnancy, the odds ratios observed for categories of years since the last full term pregnancy were: 0-2 years, odds ratio 1.16 (95% confidence interval 0.84 to 1.59); 3-6 years, odds ratio 1.21 (0.95 to 1.54); 7-9 years, odds ratio 1.04 (0.84 to 1.38); > or = 10 years, odds ratio 1.00 (reference).
CONCLUSIONS
Among multiparous women aged 25-49 years there was no association between the risk of breast cancer and the time interval since the last full term pregnancy.
目的
研究近期足月妊娠是否会增加患乳腺癌的风险。
设计
基于人群的病例对照研究。
地点
美国的八个地区。
研究对象
病例为2279名年龄在25 - 49岁之间、居住在这八个地区的经产妇，她们在1980 - 1982年间被诊断患有乳腺癌。对照是通过随机数字拨号从同一地区选取的2357名经产妇。
主要观察指标
根据自上次足月妊娠后的时间间隔来评估患乳腺癌的相对风险。
结果
病例组和对照组自上次足月妊娠后的时间间隔分布相似。在对年龄、产次和首次足月妊娠年龄进行调整后，自上次足月妊娠后的不同年份分类的比值比为：0 - 2年，比值比1.16（95%置信区间0.84至1.59）；3 - 6年，比值比1.21（0.95至1.54）；7 - 9年，比值比1.04（0.84至1.38）；≥10年，比值比1.00（参照）。
结论
在年龄为25 - 49岁的经产妇中，乳腺癌风险与自上次足月妊娠后的时间间隔之间没有关联。
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