Regezi J A, Zarbo R J, Lloyd R V
Cancer. 1987 Jan 1;59(1):64-8. doi: 10.1002/1097-0142(19870101)59:1<64::aid-cncr2820590116>3.0.co;2-q.
A spectrum of giant cell lesions was evaluated for muramidase, alpha-1 antitrypsin, alpha-1 antichymotrypsin, and S-100 protein immunoreactivity using an avidin-biotin-complex immunoperoxidase method. Peripheral giant cell granuloma, central giant cell granuloma, giant cell tumor, osteitis fibrosa cystica, cherubism, and giant cell tumor of tendon sheath showed similar patterns of reactivity. Granulomatous inflammatory lesions stained more intensely for muramidase than did noninflammatory lesions. Alpha-1-antichymotrypsin was a slightly better marker of giant cell lesions than was alpha-1-antitrypsin. Positive S-100 protein staining in half the lesions was thought to be due to the presence of Langerhans cells. The results supported the belief that giant cell lesions of bone and tendon sheath are differentiated toward cells of the mononuclear-phagocyte system and that multinucleated giant cells are derived from macrophages.
采用抗生物素蛋白-生物素-复合物免疫过氧化物酶法，对一系列巨细胞病变进行了溶菌酶、α1抗胰蛋白酶、α1抗糜蛋白酶和S-100蛋白免疫反应性评估。外周巨细胞肉芽肿、中央巨细胞肉芽肿、巨细胞瘤、纤维囊性骨炎、颌骨多囊病和腱鞘巨细胞瘤显示出相似的反应模式。肉芽肿性炎性病变的溶菌酶染色比非炎性病变更强。α1抗糜蛋白酶作为巨细胞病变的标志物比α1抗胰蛋白酶略好。半数病变中S-100蛋白染色阳性被认为是由于朗格汉斯细胞的存在。结果支持这样的观点，即骨和腱鞘的巨细胞病变向单核吞噬细胞系统的细胞分化，多核巨细胞来源于巨噬细胞。
