Yokota T, Okabayashi H, Ishihara T, Kawano H, Wakabayashi F, Miyamoto A T, Iwata T, Takahashi M, Yamashita Y, Uchino F
Department of Pathology, Kokura Memorial Hospital, Kitakyushu, Japan.
Pathol Int. 1994 Mar;44(3):182-5.
One hundred and thirty-six cardiac valves obtained surgically from 124 patients (aged 15-77 years) were examined. Microdeposition of amyloid was present in sclerotic or sclerocalcific lesions of aortic valves in 38 out of 75 (51%) and mitral valves in 21 out of 61 (34%). Amyloid deposition was not significantly related to the age of the patients. An antiserum raised against a low molecular weight protein extracted from amyloid-laden valvular tissues (about 20 g) reacted positively to amyloid in the cardiac valves. It did not react to amyloid deposition containing fibril proteins including light chain related amyloidosis, reactive amyloidosis, systemic senile amyloidosis, isolated atrial amyloidosis, beta-2-microglobulin related amyloidosis and beta protein related amyloidosis. Further, amyloid in the cardiac valves failed to react immunohistochemically to anti-AA, anti-AL, anti-TTR, anti-ANF, anti-beta 2M and anti-beta protein antibodies. These findings suggest that an unknown amyloid protein is involved in the damaged valves.
对从124例患者（年龄15 - 77岁）手术获取的136个心脏瓣膜进行了检查。在75个主动脉瓣的硬化或硬化钙化病变中，有38个（51%）存在淀粉样物质微沉积；在61个二尖瓣中，有21个（34%）存在淀粉样物质微沉积。淀粉样物质沉积与患者年龄无显著相关性。用从富含淀粉样物质的瓣膜组织中提取的一种低分子量蛋白质（约20kD）制备的抗血清，与心脏瓣膜中的淀粉样物质呈阳性反应。它对含有纤维蛋白的淀粉样物质沉积无反应，这些纤维蛋白包括轻链相关性淀粉样变性、反应性淀粉样变性、系统性老年性淀粉样变性、孤立性心房淀粉样变性、β2微球蛋白相关性淀粉样变性和β蛋白相关性淀粉样变性。此外，心脏瓣膜中的淀粉样物质对抗AA、抗AL、抗TTR、抗ANF、抗β2M和抗β蛋白抗体均无免疫组化反应。这些发现提示，一种未知的淀粉样蛋白与受损瓣膜有关。
