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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Muiesan G, Alicandri C, Rosei E A, Motolese M, Valori C

Clin Sci Mol Med Suppl. 1975 Jun;2:85s-88s. doi: 10.1042/cs048085s.

Catecholamine plasma concentrations and urinary excretion were measured together with plasma renin activity in ten patients with essential hypertension and in five normal control subjects before and after a frusemide challenge. 2. The same procedure was repeated in the same subjects 3--4 days later after pretreatment with oxprenolol. 3. Noradrenaline plasma concentrations and urinary excretion increased significantly after frusemide in all cases, returning to normal values at 30 and 60 min. Adrenaline plasma concentrations and urinary excretion were unchanged. 4. Plasma renin activity increased significantly in seven patients with hypertension and normal renin basal values, remaining unchanged in three hypertensive patients with low-renin basal values. 5. Oxprenolol suppressed the response of noradrenaline and plasma renin activity to frusemide in all cases.

在10例原发性高血压患者和5名正常对照受试者中，在速尿激发前后测量血浆儿茶酚胺浓度、尿排泄量以及血浆肾素活性。2. 3 - 4天后，在同一受试者中用氧烯洛尔预处理后重复相同程序。3. 在所有病例中，速尿后去甲肾上腺素血浆浓度和尿排泄量显著增加，在30和60分钟时恢复到正常值。肾上腺素血浆浓度和尿排泄量未改变。4. 7例高血压且肾素基础值正常的患者血浆肾素活性显著增加，3例低肾素基础值的高血压患者保持不变。5. 在所有病例中，氧烯洛尔抑制了去甲肾上腺素和血浆肾素活性对速尿的反应。

Muiesan G, Alicandri C, Rosei E A, Motolese M, Valori C

Clin Sci Mol Med Suppl. 1975 Jun;2:85s-88s. doi: 10.1042/cs048085s.

Catecholamine plasma concentrations and urinary excretion were measured together with plasma renin activity in ten patients with essential hypertension and in five normal control subjects before and after a frusemide challenge. 2. The same procedure was repeated in the same subjects 3--4 days later after pretreatment with oxprenolol. 3. Noradrenaline plasma concentrations and urinary excretion increased significantly after frusemide in all cases, returning to normal values at 30 and 60 min. Adrenaline plasma concentrations and urinary excretion were unchanged. 4. Plasma renin activity increased significantly in seven patients with hypertension and normal renin basal values, remaining unchanged in three hypertensive patients with low-renin basal values. 5. Oxprenolol suppressed the response of noradrenaline and plasma renin activity to frusemide in all cases.

在10例原发性高血压患者和5名正常对照受试者中，在速尿激发前后测量血浆儿茶酚胺浓度、尿排泄量以及血浆肾素活性。2. 3 - 4天后，在同一受试者中用氧烯洛尔预处理后重复相同程序。3. 在所有病例中，速尿后去甲肾上腺素血浆浓度和尿排泄量显著增加，在30和60分钟时恢复到正常值。肾上腺素血浆浓度和尿排泄量未改变。4. 7例高血压且肾素基础值正常的患者血浆肾素活性显著增加，3例低肾素基础值的高血压患者保持不变。5. 在所有病例中，氧烯洛尔抑制了去甲肾上腺素和血浆肾素活性对速尿的反应。