Fuhr J E, Kattine A A, Nelson H S
Department of Medical Biology, University of Tennessee Medical Center, Knoxville 37920.
J Surg Oncol. 1994 Jul;56(3):153-8. doi: 10.1002/jso.2930560305.
Fine needle aspiration analysis of intraabdominal masses is increasing in frequency. This study was designed to evaluate whether flow cytometry could be of value in the cytopathology interpretation of such specimens. Over a 4-year time span, 129 consecutive liver fine needle aspirates were evaluated by flow cytometry for DNA content, ploidy, and proliferation rate. Only excess cells remaining in the needle after cytology samples were prepared were included in this study. Overall sensitivity was 75% and specificity was 94%. In addition, flow cytometry results were pivotal for at least two specimens in achieving the appropriate diagnosis. For these reasons, it was concluded that flow cytometry could be a valuable adjunctive technology, to the cytopathologist in the interpretation of liver fine needle aspirates.
腹腔肿块的细针穿刺抽吸分析的频率正在增加。本研究旨在评估流式细胞术在此类标本的细胞病理学解读中是否具有价值。在4年的时间跨度内，对129例连续的肝脏细针穿刺抽吸物进行了流式细胞术检测，以评估DNA含量、倍性和增殖率。本研究仅纳入了制备细胞学样本后留在针内的多余细胞。总体敏感性为75%，特异性为94%。此外，流式细胞术结果对至少两个标本做出正确诊断起到了关键作用。基于这些原因，得出的结论是，流式细胞术在肝脏细针穿刺抽吸物的解读中可能是一种有价值的辅助技术，对细胞病理学家而言。
