Gujrati V R, Goyal A, Gaur S P, Singh N, Shanker K
Department of Pharmacology & Therapeutics, King George's Medical College, Lucknow, India.
Life Sci. 1994;55(4):327-35. doi: 10.1016/0024-3205(94)00735-7.
Platelet functions are becoming the useful tool for delineating the etiology of pregnancy induced hypertension. Electronmicroscopic studies, efflux and content of 5-HT in platelets and platelet aggregation responses towards various aggregating agents have been measured in 25 normotensive pregnant subjects and 31 PIH subjects. Marked decrease changes have been noted in aggregation parameters with transformation from discoid to "spiny sphere" of platelets with long pseudopods along with prolonged time for spontaneous aggregation by platelets in PIH. Serotonin release from platelets was decreased and reserpine-induced release-reaction showed enhanced kinetics in PIH. Platelet serotonin content was raised and was inversely related to platelet count with severity of syndrome. Hence, a check and balance for platelet activation and aggregation in PIH might be crucial in the development of PIH.
血小板功能正成为阐明妊娠高血压综合征病因的有用工具。对25名血压正常的孕妇和31名妊娠高血压综合征患者进行了电子显微镜研究、测量了血小板中5-羟色胺（5-HT）的流出和含量以及血小板对各种聚集剂的聚集反应。在妊娠高血压综合征患者中，随着血小板从盘状转变为带有长伪足的“棘球”，聚集参数显著降低，同时血小板自发聚集时间延长。妊娠高血压综合征患者血小板中血清素释放减少，利血平诱导的释放反应动力学增强。血小板血清素含量升高，且与血小板计数及综合征严重程度呈负相关。因此，对妊娠高血压综合征患者血小板激活和聚集的制衡可能对该病的发展至关重要。
