de Vries J I, Vellenga E, Aarnoudse J G
Eur J Obstet Gynecol Reprod Biol. 1983 Jan;14(4):209-16. doi: 10.1016/0028-2243(83)90262-9.
Plasma beta-thromboglobulin (BTG) was measured in 25 patients with pregnancy-induced hypertension (PIH), 7 of whom had severe PIH, and in 23 healthy gravidae. Also platelet counts, spontaneous platelet aggregation in vitro, and coagulation studies such as fibrinogen, fibrinogen degradation products and antithrombin III (AT III) were carried out: fetal outcome was judged by birthweight, placental weight and venous umbilical pH. Plasma BTG values of the PIH and severe PIH patients were significantly higher than those of the controls (P less than 0.05), suggesting enhanced platelet activation in the former. Compared with the controls, the entire PIH group was found to have significantly lower AT III values (P less than 0.05), more positive protamine sulphate tests (P less than 0.025), and higher plasma urate concentrations (P less than 0.01), but increased BTG values were more often observed than abnormal coagulation tests. No relationship could be demonstrated between the BTG level and fetal outcome. The significant increase in plasma BTG in PIH indicates enhanced platelet activation in these patients.
对25例妊娠高血压综合征（PIH）患者（其中7例为重度PIH）及23例健康孕妇测定了血浆β-血小板球蛋白（BTG）。同时进行了血小板计数、体外自发性血小板聚集以及凝血相关研究，如纤维蛋白原、纤维蛋白原降解产物和抗凝血酶III（AT III）；通过出生体重、胎盘重量和脐静脉血pH值判断胎儿结局。PIH患者及重度PIH患者的血浆BTG值显著高于对照组（P<0.05），提示前者血小板活化增强。与对照组相比，整个PIH组的AT III值显著降低（P<0.05），硫酸鱼精蛋白试验阳性率更高（P<0.025），血浆尿酸浓度更高（P<0.01），但BTG值升高比凝血试验异常更常见。未发现BTG水平与胎儿结局之间存在关联。PIH患者血浆BTG显著升高表明这些患者血小板活化增强。
