Da Silva e Souza M C, Gimeno M F, Gimeno A L
Centro de Estudios Farmacológicos y de Principios Naturales, Instituto de Neurobiologia, Buenos Aires, Argentina.
Fertil Steril. 1975 Dec;26(12):1250-6. doi: 10.1016/s0015-0282(16)41542-6.
The effects of norepinephrine, phentalamine, oxytocin, vasopressin, several prostaglandins, and indomethacin on the spontaneous motility of isolated guinea pig cauda epididymidis were explored. Phentolamine and indomethacin reduced the isometric peak tension of spontaneous epididymal contractions. Phentolamine also depressed the frequency. Both findings suggest that catecholamines and endogenous prostaglandins are in some way regulators of the spontaneous motility of the cauda epididymidis. Norepinephrine resulted in the development of a distinct, sustained, tonic contraction without phasic activity, whereas prostaglandins E1, E2, and F2 alpha elicited a tonic increase accompanied by frequent, superimposed, phasic contractions. Both oxytocin and vasopressin comparably enhanced epididymal motility, producing contractile responses similar to those observed with prostaglandins. Since the epididymal contractions can influence the time spent by spermatozoa in passing through the ductus epididymidis, the above-mentioned compounds could play an important role in spermatozoal transport via modulation of epididymal contractile activity. In addition, such naturally occurring substances might regulate the release of sperm from the last portion of the epididymis into the ductus deferens.
研究了去甲肾上腺素、酚妥拉明、催产素、血管加压素、几种前列腺素和吲哚美辛对离体豚鼠附睾尾自发运动的影响。酚妥拉明和吲哚美辛降低了附睾自发收缩的等长峰值张力。酚妥拉明还降低了频率。这两个发现表明，儿茶酚胺和内源性前列腺素在某种程度上是附睾尾自发运动的调节因子。去甲肾上腺素导致出现明显的、持续的强直性收缩，无相位活动，而前列腺素E1、E2和F2α引起强直性增加，并伴有频繁的、叠加的相位收缩。催产素和血管加压素均同等程度地增强了附睾运动，产生了与前列腺素相似的收缩反应。由于附睾收缩可影响精子通过附睾管的时间，上述化合物可能通过调节附睾收缩活动在精子运输中发挥重要作用。此外，这些天然存在的物质可能调节精子从附睾最后部分释放到输精管。
