Shiraki K, Moriwaki M, Sakamoto T, Khono T, Miki T
Department of Ophthalmology, Osaka City University Medical School, Japan.
Nippon Ganka Gakkai Zasshi. 1994 Jun;98(6):558-65.
Fenestration of the choriocapillaris may be lost and regained in various pathologic conditions. The purpose of this study was to observe the gradual disappearance of fenestrae with the scanning electron microscope. Pigmented rats were treated with an intravenous injection of sodium iodate. Changes in the choriocapillaris were produced by damaging retinal pigment epithelium. The eyes were processed for styrene embedded cracking on the third, fifth, and seventh days. Dense clusters of fenestrae were seen at the luminal surface facing retina on the third day. These clusters were surrounded by protrusion of cellular surface. The clusters of fenestrae were smaller with some variation in size on the fifth and seventh days. The protrusion between the clusters became flatter and wider. Some endothelial cells had a flat surface with tiny clusters of fenestrae. Although there was loss of fenestrae with smaller clusters and some variation in size, the tendency of the fenestrae to cluster was sustained in the same way as during the reformation of fenestrae in the choriocapillaris after laser photocoagulation.
在各种病理状况下，脉络膜毛细血管的窗孔可能会消失并重新出现。本研究的目的是利用扫描电子显微镜观察窗孔的逐渐消失过程。给色素沉着大鼠静脉注射碘酸钠。通过损伤视网膜色素上皮来引发脉络膜毛细血管的变化。在第三天、第五天和第七天对眼睛进行处理，以便进行苯乙烯包埋裂解。在第三天，在面向视网膜的管腔表面可见密集的窗孔簇。这些簇被细胞表面的突起所包围。在第五天和第七天，窗孔簇变小，大小有一些变化。簇之间的突起变得更平更宽。一些内皮细胞表面平坦，有微小的窗孔簇。尽管窗孔有丢失，簇变小且大小有一些变化，但窗孔聚集的趋势与激光光凝后脉络膜毛细血管窗孔重新形成过程中保持相同。
