Kohno T
Department of Ophthalmology, Osaka City University Medical School, Japan.
Osaka City Med J. 1993 Nov;39(2):151-66.
The purpose of this study is to reveal the process for the clustered fenestra-formation in endothelial cells. Such a process was investigated in two experimental models by using scanning electron microscopy. One was photocoagulated sites of the choriocapillaris. The other was abnormal vessels seen in urethane-induced retinopathy. In the photocoagulation experiment, no fenestra was seen at the center of the lesion 5 or 7 days after photocoagulation. However, when the observing regions were moved away from the center, clusters of several fenestrae appeared. Further away from the center, larger clusters of fenestrae were observed. Fenestrae were distributed in regular fashion in each cluster regardless of size of the cluster. Similar clusters of fenestrae were found in urethane-induced retinopathy. Fenestration was found in the retinal vessels which were located near the choroid. However, the clusters of fenestrae decreased in number in such retinal vessels located near the vitreous. Based on those observations, the author suggests a hypothesis regarding acquisition of clustered fenestrae in pathologic conditions.
本研究的目的是揭示内皮细胞中簇状窗孔形成的过程。通过扫描电子显微镜在两种实验模型中对这一过程进行了研究。一种是脉络膜毛细血管的光凝部位。另一种是在氨基甲酸乙酯诱导的视网膜病变中出现的异常血管。在光凝实验中，光凝后5天或7天在病变中心未见窗孔。然而，当观察区域从中心移开时，出现了几个窗孔的簇。离中心更远的地方，观察到更大的窗孔簇。无论簇的大小如何，窗孔在每个簇中均呈规则分布。在氨基甲酸乙酯诱导的视网膜病变中也发现了类似的窗孔簇。在靠近脉络膜的视网膜血管中发现了窗孔。然而，在靠近玻璃体的此类视网膜血管中，窗孔簇的数量减少。基于这些观察结果，作者提出了一个关于在病理条件下获得簇状窗孔的假说。
