Fuchs G J, Ausayakhun S, Ruckphaopunt S, Tansuhaj A, Suskind R M
Research Institute For Health Sciences, Chiang Mai University, Thailand.
Am J Clin Nutr. 1994 Aug;60(2):293-8. doi: 10.1093/ajcn/60.2.293.
One hundred seventy-eight children from three villages were studied in a cross-sectional fashion to evaluate the efficacy of conjunctival impression cytology (CIC) to characterize vitamin A status of individual children and populations of children and to examine the relationship of vitamin A status to nutritional status. Although children with abnormal CIC results had lower retinol concentrations than those with normal CIC results (P < 0.02), CIC exhibited poor sensitivity and specificity. Results of a CIC prevalence criterion were concordant with plasma retinol criteria in characterizing the vitamin A status of each community. Plasma retinol measurements, but not CIC, were associated with height (P < 0.003) and severe stunting (P < 0.001). We conclude that although CIC was a poor indicator of an individual child's vitamin A status, it accurately characterized the risk of vitamin A deficiency of communities. Furthermore, vitamin A deficiency defined by circulating retinol measurements but not CIC is associated with poor linear growth.
对来自三个村庄的178名儿童进行了横断面研究，以评估结膜印迹细胞学检查（CIC）在确定个体儿童及儿童群体维生素A状况方面的有效性，并研究维生素A状况与营养状况之间的关系。尽管CIC结果异常的儿童血清视黄醇浓度低于结果正常的儿童（P < 0.02），但CIC的敏感性和特异性较差。CIC患病率标准的结果与血浆视黄醇标准在确定每个社区的维生素A状况方面是一致的。血浆视黄醇测量值而非CIC与身高（P < 0.003）和严重发育迟缓（P < 0.001）相关。我们得出结论，尽管CIC在个体儿童维生素A状况方面是一个较差的指标，但它能准确地反映社区维生素A缺乏的风险。此外，通过循环视黄醇测量而非CIC确定的维生素A缺乏与线性生长不良有关。
