Gadomski A M, Kjolhede C L, Wittpenn J, Bulux J, Rosas A R, Forman M R
Department of International Health, Johns Hopkins School of Hygiene and Public Health, Baltimore, MD.
Am J Clin Nutr. 1989 Mar;49(3):495-500. doi: 10.1093/ajcn/49.3.495.
By use of sensitivity and specificity analysis, conjunctival impression cytology (CIC) was compared with fasting serum vitamin A levels and relative dose response (RDR) of Guatemalan children. One impression was taken from the temporal bulbar aspect of each eye, fasting serum vitamin A levels were then drawn, 480 RE of oil-based retinyl palmitate was given, and a 5-h postdosing vitamin A level was drawn (RDR procedure). For a 20% RDR cutoff, the sensitivity of CIC was 23% with a specificity of 80% and a positive predictive value of 9% (n = 213 children). Compared with fasting vitamin A levels alone (with 0.70 mumol/L as abnormal), the sensitivity of CIC was 26%, specificity was 81%, and positive predictive value was 22% (n = 221 children). There was no significant difference in the mean serum retinol level between those with abnormal and normal CIC. In this study population CIC does not identify the same group of children with marginal vitamin A as identified biochemically.
通过敏感性和特异性分析，对危地马拉儿童的结膜印迹细胞学检查（CIC）与空腹血清维生素A水平及相对剂量反应（RDR）进行了比较。从每只眼睛的颞侧球结膜处获取一个印迹，然后采集空腹血清维生素A水平，给予480 RE油基棕榈酸视黄酯，给药5小时后采集维生素A水平（RDR程序）。对于20%的RDR临界值，CIC的敏感性为23%，特异性为80%，阳性预测值为9%（n = 213名儿童）。与单独的空腹维生素A水平（以0.70 μmol/L为异常）相比，CIC的敏感性为26%，特异性为81%，阳性预测值为22%（n = 221名儿童）。CIC异常和正常的儿童之间血清视黄醇平均水平无显著差异。在该研究人群中，CIC所识别出的维生素A边缘缺乏儿童群体与生化方法所识别出的不同。
