Sasaki C T, Yue A, Enriques R
Department of Surgery, Yale University School of Medicine, New Haven, Conn 06510.
Arch Otolaryngol. 1976 Dec;102(12):753-5. doi: 10.1001/archotol.1976.00780170071012.
Calcifying epithelioma of Malherbe, or benign pilomatrixoma, is described as a skin tumor histologically composed of (1) "shadow" cells, (2) basophilic cells, (3) foreign body cells, and (4) intracellular and stromal calcifications. The dermatologic literature describes this tumor as a small benign lesion that never exhibits a malignant propensity. However, the recent surgical literature associates its enlarged size with its occasional aggressive behavior. In this regard, tumor dimension appears to influence prognosis. The term "giant calcifying epithelioma" appears taxonomically justified as a clinical description of this malignant tumor possessing histologic similarity to benign pilomatrixoma. The surgical literature has not previously stressed the mixed histologic characteristics of this pathologic variant. We report a case that demonstrates the malignant potential of giant calcifying epithelioma. The clinician should be alerted against a false security provided by the benign appearance of preoperative histologic sampling.
马尔赫布钙化上皮瘤，即良性毛母质瘤，被描述为一种皮肤肿瘤，其组织学上由（1）“影子”细胞、（2）嗜碱性细胞、（3）异物细胞以及（4）细胞内和间质钙化组成。皮肤病学文献将此肿瘤描述为一种小的良性病变，从不表现出恶性倾向。然而，近期的外科文献将其增大的尺寸与其偶尔的侵袭性行为联系起来。在这方面，肿瘤大小似乎会影响预后。“巨大钙化上皮瘤”这一术语作为对这种与良性毛母质瘤具有组织学相似性的恶性肿瘤的临床描述，在分类学上似乎是合理的。外科文献此前并未强调这种病理变体的混合组织学特征。我们报告一例病例，展示了巨大钙化上皮瘤的恶性潜能。临床医生应警惕术前组织学取样的良性外观所带来的错误安全感。
