Lindoff C, Astedt B
Department of Obstetrics and Gynecology, University Hospital, Lund, Sweden.
Am J Obstet Gynecol. 1994 Jul;171(1):60-4. doi: 10.1016/s0002-9378(94)70078-8.
Our purpose was to study the plasma concentrations of the plasminogen activator of urokinase type and its specific inhibitor of placental type in pregnancies complicated by hypertension or fetal growth retardation.
Consecutive patients with pregnancy-induced hypertension (n = 17), mild preeclampsia (n = 17), severe preeclampsia (n = 19), and intrauterine growth retardation (n = 19) were studied. Blood samples were obtained just before delivery (mean 2 days). Women with normal pregnancies (n = 40), longitudinally followed between the tenth and fortieth gestational weeks, served as a control group.
The plasma concentrations of the urokinase type antigen were significantly lower in women with severe preeclampsia or intrauterine growth retardation than those in women with normal pregnancies (p < 0.001). In all four groups with complicated pregnancies the antigen concentrations of the urokinase type and its inhibitor were significantly correlated with both placental weight and birth weight.
The plasma concentration of the urokinase type antigen would appear to reflect placental function, and both the antigen and its inhibitor concentrations are correlated with placental and fetal growth.
我们的目的是研究妊娠合并高血压或胎儿生长受限患者中尿激酶型纤溶酶原激活剂及其胎盘型特异性抑制剂的血浆浓度。
对连续的妊娠高血压患者（n = 17）、轻度子痫前期患者（n = 17）、重度子痫前期患者（n = 19）和宫内生长受限患者（n = 19）进行研究。在分娩前（平均2天）采集血样。将在妊娠第10周至第40周期间进行纵向随访的正常妊娠女性（n = 40）作为对照组。
重度子痫前期或宫内生长受限女性的尿激酶型抗原血浆浓度显著低于正常妊娠女性（p < 0.001）。在所有四组妊娠合并症患者中，尿激酶型抗原及其抑制剂的浓度均与胎盘重量和出生体重显著相关。
尿激酶型抗原的血浆浓度似乎反映了胎盘功能，并且抗原及其抑制剂的浓度均与胎盘和胎儿生长相关。
