Fanti P A, Tosti A, Bardazzi F, Guerra L, Morelli R, Cameli N
Department of Dermatology, University of Bologna, Italy.
Am J Dermatopathol. 1994 Apr;16(2):167-70.
Fourteen patients, four male and 10 female and ranging in age from 11 to 57 years, affected by longstanding alopecia areata that had not responded to sensitizing treatments, were submitted to scalp biopsy. Five patients had alopecia totalis and nine had alopecia universalis. The biopsy was performed on a scalp area that had been bald for > or = 1 year. We distinguished four distinct pathological patterns, which we termed "established bald patch," "early regrowth," "telogen," and "scarring," in four, seven, one, and two patients, respectively. Our study shows that, from a pathological point of view, nonresponder patients constitute a heterogeneous population. The pathological study of the scalp helps predict therapeutic failure only in the small proportion of nonresponder patients that shows a scarring pathological pattern.
14例患者（4例男性，10例女性，年龄在11至57岁之间），患有长期斑秃且对致敏治疗无反应，接受了头皮活检。5例患者为全秃，9例为普秃。活检在秃发≥1年的头皮区域进行。我们分别在4例、7例、1例和2例患者中区分出四种不同的病理模式，我们将其称为“已形成的秃斑”、“早期再生”、“休止期”和“瘢痕性”。我们的研究表明，从病理学角度来看，无反应患者构成了一个异质性群体。头皮的病理研究仅在一小部分显示瘢痕性病理模式的无反应患者中有助于预测治疗失败。
