Torsteinsdóttir S, Georgsson G, Gísladóttir E, Rafnar B, Pálsson P A, Pétursson G
Institute for Experimental Pathology, University of Iceland, Keldur, Reykjavík.
Ann N Y Acad Sci. 1994 Jun 6;724:159-61. doi: 10.1111/j.1749-6632.1994.tb38905.x.
The time course and titers of antibodies did not correlate with the severity of CNS lesions whereas the CMI did, indicating that CMI may play an important role in lesion development. The correlation of the number of CD8 positive cells in the CSF with the severity of lesions and the reversed ratio of CD4/CD8 positive cells in the diffusely infiltrated neuroparenchyma indicates that the CD8 positive T cells may be an important effector cell in the induction of CNS lesions.
抗体的时间进程和滴度与中枢神经系统病变的严重程度无关，而细胞介导免疫（CMI）则相关，这表明CMI可能在病变发展中起重要作用。脑脊液中CD8阳性细胞数量与病变严重程度的相关性以及弥漫性浸润神经实质中CD4/CD8阳性细胞的倒置比例表明，CD8阳性T细胞可能是诱导中枢神经系统病变的重要效应细胞。
