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Lectin effects on HIV-1 infectivity.

作者信息

Hammar L, Hirsch I, Machado A, De Mareuil J, Baillon J, Chermann J C

机构信息

Department of Veterinary Virology, Biomedical Center, Uppsala, Sweden.

出版信息

Ann N Y Acad Sci. 1994 Jun 6;724:166-9. doi: 10.1111/j.1749-6632.1994.tb38907.x.

DOI:10.1111/j.1749-6632.1994.tb38907.x
PMID:8030938
Abstract

Lectins with specificity for terminal mannose residues and anti-mannan antibodies are assumed to neutralize HIV-1 by binding to the viral glycoproteins. In this report we demonstrate that one such agents, the lectin from Galanthus nivalis (GNA), blocks infection also at the target cell level.

摘要

相似文献

1
Lectin effects on HIV-1 infectivity.
Ann N Y Acad Sci. 1994 Jun 6;724:166-9. doi: 10.1111/j.1749-6632.1994.tb38907.x.
2
Lectin-mediated effects on HIV type 1 infection in vitro.凝集素对1型人类免疫缺陷病毒体外感染的影响
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Marked depletion of glycosylation sites in HIV-1 gp120 under selection pressure by the mannose-specific plant lectins of Hippeastrum hybrid and Galanthus nivalis.在朱顶红和雪花莲的甘露糖特异性植物凝集素的选择压力下,HIV-1 gp120中糖基化位点显著减少。
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Differences in the mannose oligomer specificities of the closely related lectins from Galanthus nivalis and Zea mays strongly determine their eventual anti-HIV activity.来自雪花莲和玉米的密切相关凝集素的甘露寡糖特异性的差异强烈决定了它们最终的抗 HIV 活性。
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Envelope glycoproteins of HIV-1, HIV-2, and SIV purified with Galanthus nivalis agglutinin induce strong immune responses.用雪花莲凝集素纯化的HIV-1、HIV-2和SIV包膜糖蛋白可诱导强烈的免疫反应。
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Mannose-specific plant lectins from the Amaryllidaceae family qualify as efficient microbicides for prevention of human immunodeficiency virus infection.来自石蒜科的甘露糖特异性植物凝集素堪称预防人类免疫缺陷病毒感染的高效杀菌剂。
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Differential in vitro inhibitory activity against HIV-1 of alpha-(1-3)- and alpha-(1-6)-D-mannose specific plant lectins: implication for microbicide development.α-(1-3)-和α-(1-6)-D-甘露糖特异性植物凝集素对HIV-1的体外抑制活性差异:对杀微生物剂开发的意义。
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Removal of two high-mannose N-linked glycans on gp120 renders human immunodeficiency virus 1 largely resistant to the carbohydrate-binding agent griffithsin.去除 gp120 上的两个高甘露糖型 N-连接聚糖可使人类免疫缺陷病毒 1 对碳水化合物结合剂 griffithsin 产生很大的抗性。
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Binding of Galanthus nivalis lectin to Chlamydia trachomatis and inhibition of in vitro infection.
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Related lectins from snowdrop and maize differ in their carbohydrate-binding specificity.来自雪花莲和玉米的相关凝集素在碳水化合物结合特异性方面存在差异。
Biochem Biophys Res Commun. 2009 Mar 6;380(2):260-5. doi: 10.1016/j.bbrc.2009.01.048. Epub 2009 Jan 22.

引用本文的文献

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Overview of the Structure⁻Function Relationships of Mannose-Specific Lectins from Plants, Algae and Fungi.植物、藻类和真菌中甘露糖特异性凝集素的结构-功能关系概述。
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A dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN)-related protein is highly expressed on human liver sinusoidal endothelial cells and promotes HIV-1 infection.一种树突状细胞特异性细胞间黏附分子3结合非整合素(DC-SIGN)相关蛋白在人肝窦内皮细胞上高表达,并促进HIV-1感染。
J Exp Med. 2001 Mar 19;193(6):671-8. doi: 10.1084/jem.193.6.671.