In vivo bactericidal activities of ciprofloxacin and pefloxacin in an experimental model of Serratia marcescens endocarditis.
作者信息
Juvin M E, Potel G, Caillon J, Xiong Y Q, Bugnon D, Le Conte P, Baron D I, Drugeon H B
机构信息
Laboratoire d'Antibiologie, Faculté de médecine, Centre Hospitalier Universitaire, France.
出版信息
Antimicrob Agents Chemother. 1994 Apr;38(4):883-5. doi: 10.1128/AAC.38.4.883.
Abstract
The critical concentrations of pefloxacin and ciprofloxacin in serum, corresponding to the lowest concentration in serum able to achieve a 2-log-unit reduction in the CFU in vegetations after a 24-h exposure at a steady-state concentration obtained by a continuous intravenous infusion, were determined in an experimental model of Serratia marcescens endocarditis in rabbits. In vitro data showed that the MICs of ciprofloxacin and pefloxacin were 0.06 and 0.25 mg/liter, respectively. The killing curves indicated a maximum killing rate at a concentration four times that of the MICs. In vivo, the critical concentrations of pefloxacin and ciprofloxacin in serum were 0.4 and 0.24 mg/liter, respectively, corresponding to a concentration of four times the MICs.
摘要
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