Juvin M E, Potel G, Caillon J, Xiong Y Q, Bugnon D, Le Conte P, Baron D I, Drugeon H B
Laboratoire d'Antibiologie, Faculté de médecine, Centre Hospitalier Universitaire, France.
Antimicrob Agents Chemother. 1994 Apr;38(4):883-5. doi: 10.1128/AAC.38.4.883.
The critical concentrations of pefloxacin and ciprofloxacin in serum, corresponding to the lowest concentration in serum able to achieve a 2-log-unit reduction in the CFU in vegetations after a 24-h exposure at a steady-state concentration obtained by a continuous intravenous infusion, were determined in an experimental model of Serratia marcescens endocarditis in rabbits. In vitro data showed that the MICs of ciprofloxacin and pefloxacin were 0.06 and 0.25 mg/liter, respectively. The killing curves indicated a maximum killing rate at a concentration four times that of the MICs. In vivo, the critical concentrations of pefloxacin and ciprofloxacin in serum were 0.4 and 0.24 mg/liter, respectively, corresponding to a concentration of four times the MICs.
在兔粘质沙雷氏菌心内膜炎实验模型中，测定了培氟沙星和环丙沙星在血清中的临界浓度，该临界浓度对应于通过持续静脉输注达到稳态浓度后，在24小时暴露后能够使赘生物中CFU减少2个对数单位的血清最低浓度。体外数据显示，环丙沙星和培氟沙星的MIC分别为0.06和0.25毫克/升。杀菌曲线表明，在浓度为MIC的四倍时杀菌率最高。在体内，培氟沙星和环丙沙星在血清中的临界浓度分别为0.4和0.24毫克/升，相当于MIC的四倍浓度。
