去羟肌苷片中抗酸剂对异烟肼生物利用度的影响。
Effect of antacids in didanosine tablet on bioavailability of isoniazid.
作者信息
Gallicano K, Sahai J, Zaror-Behrens G, Pakuts A
机构信息
Bureau of Drug Research, Sir Frederick Banting Research Centre, Ottawa, Ontario, Canada.
出版信息
Antimicrob Agents Chemother. 1994 Apr;38(4):894-7. doi: 10.1128/AAC.38.4.894.
Abstract
The antacids in two didanosine placebo tablets had no significant effect on the plasma pharmacokinetics of a single oral dose of 300 mg of isoniazid administered to 12 healthy volunteers. These results suggest that isoniazid bioavailability will be unaffected by the antacids in didanosine tablets when the two medications are administered simultaneously to human immunodeficiency virus-seropositive patients.
摘要
给12名健康志愿者口服300毫克异烟肼单剂量后，两种去羟肌苷安慰剂片剂中的抗酸剂对其血浆药代动力学无显著影响。这些结果表明，当这两种药物同时给予人类免疫缺陷病毒血清反应阳性患者时，去羟肌苷片剂中的抗酸剂不会影响异烟肼的生物利用度。
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